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The Role of Testing for BRCA1 and BRCA2 Mutations in Cancer Prevention

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In May 2013, Angelina Jolie, the actress and director, announced in an op-ed in the New York Times that she carried a BRCA1 mutation and had had a preventive double mastectomy. Jolie’s message was striking—by identifying a mutation in a cancer susceptibility gene, one of the most famous actresses of our generation dramatically reduced her risk of dying from cancer.

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